| 摘要 |
The invention relates to a novel group of compounds of Formula (I) or salts thereof:;;wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I). |
| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein: Y represents CH or N; Z1-Z2 represents a group selected from C(R6)═CH, N═CH and C(R6)═N; where
R6 represents hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, difluoromethyl, trifluoromethyl or cyclopropyl; n is 0, 1 or 2; R1 represents C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, fluoroC1-4alkyl, aminoC1-4alkyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C3-6cycloalkyl, —(CH2)pNHCOCH3, —(CH2)pNHSO2CH3, —(CH2)pNHCONH2, —(CH2)pNHCONR2R3, —(CH2)pNR2R3, —(CH2)pSO2NH2, —(CH2)pSO2NR2R3, —(CH2)pCONH2, —(CH2)pCONR2R3 or —(CH2)p—R7; where
p is 0, 1, 2 or 3;R2 represents hydrogen or C1-3alkyl;R3 represents C1-3alkyl; andR7 represents phenyl;R7 represents a 5 or 6 membered monocyclic heteroaryl ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S; orR7 represents a monocyclic 4, 5, or 6 membered heterocyclic ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S;wherein R7 is optionally substituted by 1 or 2 substituents selected from C1-4alkyl, trifluoromethyl, C1-4alkoxy, fluoro, chloro, bromo, and cyano; R4 represents hydrogen, fluoro, chloro, bromo, cyano or trifluoromethyl; and R5 represents hydrogen, fluoro, chloro or bromo. |
