Transmucosal taxane composition

摘要

The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual mucosa. The present invention provides a method for treating cancer by buccal or sublingual administration of the pharmaceutical composition to a subject. The pharmaceutical composition comprises a taxane, a non-ionic surfactant, a viscosity enhancing agent, an adhesive agent, and an alcohol solvent at pH 4-6.

主权项

1. A pharmaceutical formulation for buccal or sublingual administration comprising 0.15-10% (w/v) of a taxane, 20-60% (w/v) of anon-ionic surfactant, a viscosity enhancing agent to provide a viscosity of 200-400 CP, 2-30% (w/v) of an adhesive agent, and 10-75% (w/v) of ethanol, wherein the pH of the pharmaceutical formulation is 4-6, and the taxane is selected from the group consisting of docetaxel, paclitaxel, cabazitaxel, and larotaxel.