Iterative Discovery Of Neoepitopes And Adaptive Immunotherapy And Methods Therefor

摘要

Contemplated cancer treatments comprise recursive analysis of patient-, cancer-, and location-specific neoepitopes from various biopsy sites of a patient after treatment or between successive rounds of immunotherapy and/or chemotherapy to inform further immunotherapy. Recursive analysis preferably includes various neoepitope attributes to so identify treatment relevant neoepitopes.

主权项

1. A method of guided immunotherapy for a patient diagnosed with a tumor, comprising:
receiving omics data for tumor cells in a first location in a patient, and receiving omics data for tumor cells in a second location in a patient; using the omics data to determine respective neoepitopes in the tumor cells of the first and second locations; identifying treatment relevant neoepitopes in the tumor cells of the first and second locations using at least one of a group attribute, a location attribute, a function attribute, a metabolic attribute, and a pathway attribute; and creating an immunotherapeutic composition using the treatment relevant neoepitopes, and administering the immunotherapeutic composition to the patient.