发明名称 |
A STABILIZED VARIANT OF ACTIVIN IIB RECEPTOR |
摘要 |
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided. |
申请公布号 |
HRP20161450(T1) |
申请公布日期 |
2017.01.13 |
申请号 |
HR2016P001450T |
申请日期 |
2016.11.03 |
申请人 |
Amgen Inc. |
发明人 |
Sun, Jeonghoon;Tam, Lei-Ting Tony;Michaels, Mark Leo;Boone, Thomas C.;Deshpande, Rohini;Li, Yue-Sheng;Han, Hq |
分类号 |
C07K14/495;C07K14/71 |
主分类号 |
C07K14/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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