METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID SEQUENCING

摘要

The present invention is directed to methods, compositions and systems for capturing and analyzing sequence information contained in targeted regions of a genome. Such targeted regions may include exomes, partial exomes, introns, combinations of exonic and intronic regions, genes, panels of genes, and any other subsets of a whole genome that may be of interest.

主权项

1. A nucleic acid sequencing library comprising a plurality of nucleic acid fragments from a genomic sample, wherein:
(a) the plurality of nucleic acid fragments includes fragments from two or more disparate portions of the genomic sample; and (b) fragments within the plurality of nucleic acid fragments that are less than 1 kb apart in the genomic sample share a common barcode.