Composition and methods for repair of connective tissue

摘要

Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.

主权项

1. A connective tissue repair construct comprising:
an acellular scaffold comprising collagen and elastin that is colonized by host tissue cells in vivo; and a hydrogel material comprising at least one bioactive agent that stimulates tendon cell growth and tissue repair, wherein the hydrogel material is positioned adjacent to the scaffold but does not surround the scaffold and the scaffold, or any portion thereof, does not surround the hydrogel material.