Drug delivery from rapid gelling polymer composition

摘要

Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.

主权项

1. A drug-delivery system comprising:
a first container comprising a first component consisting of a sulfhydryl group-containing compound of formula: Compound1-(SH)m wherein m≧3, the first container further comprising a hydrophobic drug in a micelle, where the micelle is formed from a sulfhydryl group-containing thiol compound and an A-B block copolymer where A is a poly(alkylene oxide) and B is a degradable polyester; and a second container comprising a second component consisting of a sulfhydryl reactive group-containing compound of formula: Compound2-Yn, wherein Y is a sulfhydryl reactive acrylate group and wherein n≧3; wherein each of Compound1 and Compound2 is a multi-arm polymer comprising polyalkylene oxide; wherein a biocompatible gel forms in less than one minute after contact between the contents of the first container and the contents of the second container, the gel comprising covalent bonds formed between the sulfhydryl reactive groups of the second component and the sulfhydryl groups of each of the first component and the thiol compound; and wherein the hydrophobic drug is admixed in the biocompatible gel.