METHOD FOR PREPARING A SITE-SPECIFIC PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE
摘要
The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life.
申请公布号
HK1163120(A1)
申请公布日期
2016.04.08
申请号
HK20120103382
申请日期
2012.04.05
申请人
HANMI SCIENCE CO. LTD.
发明人
SONG, DAE HAE;SHIN, JAE HEE;LEE, JAE MIN;PARK, YOUNG KYUNG;KWON, SE CHANG;LEE, GWAN SUN