3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-on-forbindelser som MTOR-kinasehæmmere til onkologiindikationer og sygdomme associeret med MTOR/P13K/AKT-vejen

摘要

Provided herein are Heteroaryl Compounds having the following structure:
wherein R 1 -R 3 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and a Heteroaryl Compound provided herein for use in a method of treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.