| 发明名称 | Microrna patterns for the diagnosis, prognosis and treatment of melanoma | ||
| 摘要 | The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof. | ||
| 申请公布号 | US9238838(B2) | 申请公布日期 | 2016.01.19 |
| 申请号 | US201414265337 | 申请日期 | 2014.04.29 |
| 申请人 | Ramot at Tel Aviv University Ltd.;Tel Hashomer Medical Research Infrastructure and Services Ltd. | 发明人 | Markel Gal;Greenberg Eyal;Schachter Jacob |
| 分类号 | C12Q1/68;C07H21/02;C07H21/04;A61K48/00;A61K31/7105 | 主分类号 | C12Q1/68 |
| 代理机构 | Booth Udall Fuller, PLC | 代理人 | Fuller Rodney J.;Booth Udall Fuller, PLC |
| 主权项 | 1. A method for diagnosing melanoma in a subject, the method comprising: (a) obtaining from the subject a sample of peripheral blood comprising RNA; and (b) determining, in said RNA, the presence of a plurality of oncogenic miRNAs (miRs), comprising miR-374a and at least one miRNA selected from the group consisting of: miR-301a, SNORD-38b, miR-29c, miR-342-3p, miR-451 and miR-29a, wherein the presence of the plurality of oncogenic miRs is indicative of the subject having melanoma. | ||
| 地址 | Tel Aviv IL | ||