| 摘要 |
The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity. |
| 主权项 |
1. A glucagon peptide comprising SEQ ID NO 1, wherein X17 represents Lys, X18 represents Lys and X21 represents Glu, up to five amino acid substitutions in amino acid positions X2, X10, X12, X16, X20, X24, X25, X27, X28, X29 and/or X30 of said glucagon peptide, and a substituent comprising two or more negatively charged moieties, wherein one of the said negatively charged moieties is distal of a lipohilic moiety and where the said moiety is attached at the epsilon position of a Lys, at the delta position of an Orn, or at the sulphur of a Cys, in one or more of the following amino acid positions of said a glucagon peptide: X10, X12, X20, X24, X28, X29, and/or X30 or a pharmaceutically acceptable salt, amide, acid or prodrug thereof. |
