METHOD FOR ADMINISTERING IGF-I

摘要

PROBLEM TO BE SOLVED: To provide a medicine comprising IGF-I (insulin-like growth factor-I) administered in a fashion such that the maximum favorable biological activity of IGF-I is achieved and maintained in the treatment of chronic disorders with minimized unfavorable side effects for the treatment of the chronic disorders (e.g. renal failure or diabetes) in the mammal. SOLUTION: There is provided the medicine comprising IGF-I administered in the fashion as follows: IGF-I is administered to provide an exposure to the mammal over a period of time during which the maximum biological response is generated. The administration is then discontinued for a period of time equal to or less than the period of time during which the IGF-I was previously administered, and the IGF-I is subsequently administered to provide the exposure to the mammal over a period of time that provides the maximum biological response. The administration is then discontinued for a period of time equal to or less than the period of time during which the IGF-I was just previously administered, and the pattern of the administration and discontinuance of the administration is repeated over a period of time necessary to achieve or maintain the sustained biological response in the mammal. COPYRIGHT: (C)2009,JPO&INPIT