3-(1H-TETRAZOL-5-YL)-4(3H)-QUINAZOLINONES AND PROCESS FOR THE PREPARATION THEREOF

摘要

Title compds. (I)[R=H, C1-4 lower alkyl, Ph; R1=H, Me, methoxy, halo, 6,7-methylene dioxy , useful as an anti-allergic agent, are prepd. Thus, a mixt. contg. 7.5 g 2-methyl-6-nitro-N(1H-tetrazol-5-yl) benzamide in 100 ml 1N-NaOH and 0.5 g 5%-Pd/C was hydrogenated in Parr at 3.3 atm for 75 min and treated with 100 ml 1N-HCl to 2-amino- 6-methyl-N-(1H-tetrazol-5-yl) benzamide.