Nucleic Acids Encoding Antibody Molecules Which Bind IL-17A and IL-17F

摘要

The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

主权项

1. A method of treating an IL-17A and/or IL-17F mediated pathological condition in a mammal comprising the step of administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a neutralising antibody which binds human IL-17A and human IL-17F, wherein the neutralising antibody cross-blocks the binding of an antibody that binds human IL-17A and human IL-17F and has a heavy chain comprising sequence given in SEQ ID NOs:9 or 15 and a light chain comprising sequence given in SEQ ID NOs:7 or 11 to human IL-17A and/or human IL-17F and/or IL-17A/F heterodimer and/or is cross-blocked from binding human IL-17A and/or human IL-17F and/or IL-17A/F heterodimer by the antibody that binds human IL-17A and human IL-17F and has the heavy chain comprising sequence given in SEQ ID NOs:9 or 15 and the light chain comprising sequence given in SEQ ID NOs:7 or 11, in combination with one or more pharmaceutically acceptable excipients, diluents or carriers.