发明名称 |
A RAPID AND EFFICIENT BIOORTHOGONAL LIGATION REACTION AND BORON-CONTAINING HETEROCYCLES USEFUL IN CONJUCTION THEREWITH |
摘要 |
A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an α-effect amine in aqueous solution at a temperature between about -5C to 55C, and a pH between 2 and 8 to produce an adduct. A process is also provided comprising: contacting a composition having a boron atom bonded to a sp2 hybridized carbon, the boron having at least one labile substituent, conjugated with a cis-carbonyl, with an α-effect amine, in an aqueous medium for a time sufficient to form an adduct, which may proceed to further products |
申请公布号 |
WO2015164213(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
WO2015US26456 |
申请日期 |
2015.04.17 |
申请人 |
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK |
发明人 |
TUTTLE, SUSAN, BANE;OZLEM, DILEK;KAMALIKA, MUKHERJEE |
分类号 |
C07F5/02;A61K31/69 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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