发明名称 |
Methods and compositions for sleep disorders and other disorders |
摘要 |
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations. |
申请公布号 |
US9168258(B2) |
申请公布日期 |
2015.10.27 |
申请号 |
US201314066987 |
申请日期 |
2013.10.30 |
申请人 |
INTRA-CELLULAR THERAPRIES, INC. |
发明人 |
Mates Sharon;Fienberg Allen;Wennogle Lawrence P. |
分类号 |
A61K31/535;A01N43/58;A01N43/60;A61K31/50;A61K31/495;A61K9/48;A61K31/5383;A61K31/44;A61K31/4985;A61K45/06;C07D471/14;C07D498/14 |
主分类号 |
A61K31/535 |
代理机构 |
Hoxie & Associates LLC |
代理人 |
Hoxie & Associates LLC |
主权项 |
1. A pharmaceutical composition in oral unit dose form comprising an amount of 10 mg or less of a Compound of Formula I:wherein X is O, —NH or —N(CH3); and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form, in combination or association with a pharmaceutically acceptable diluent or carrier, provided that in the case of a salt, the weight is calculated as the free base, where the amount of the Compound of Formula I:
a) is sufficient to block the 5-HT2A receptor; and b) either does not block, or minimally blocks the dopamine D2 receptor. |
地址 |
New York NY US |