| 摘要 |
PROBLEM TO BE SOLVED: To provide novel polymorphic and hydrate forms and salts of 6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline, which is a protein tyrosine kinase modulator, particularly an inhibitor of c-Met, and production methods thereof.SOLUTION: The invention relates to novel polymorphic and hydrate forms and salts represented by the formula (I) in the figure which have an X-ray powder diffraction (XRPD) pattern comprising peaks at specific diffraction angles (2&thetas;) and an IR spectrum comprising peaks at specific absorption bands (cm), to pharmaceutical compositions comprising the same, to the therapeutic and/or prophylactic use of such compositions, and to new manners for producing the compounds. |
