CARBAMOYL HYDRAZINE DERIVATIVES AS FORMYL PEPTIDE MODULATORS

摘要

The present invention relates to carbamoyl hydrazine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the FPR receptor.

主权项

1. A compound represented by Formula I: R1 is H, optionally substituted C1-6alkyl, C1-6haloalkyl, optionally substituted C3-8cycloalkyl, optionally substituted C6-10aryl, optionally substituted heterocycle, halogen, —OR10, —C2-6alkenyl, —C2-6alkynyl, —CN, —C(O)R11, amine, amide, urea, sulfonamide, sulfone, sulfoxide, sulfide, sulfonic acid, nitro, phosphate or phosphonic acid; R2 is H, optionally substituted C1-6alkyl, C1-6haloalkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C6-10aryl, optionally substituted heterocycle, halogen, —OR10, —C2-6alkenyl, —C2-6 alkynyl, —CN, —C(O)R11, amine, amide, urea, sulfonamide, sulfone, sulfoxide, sulfide, sulfonic acid, nitro, phosphate or phosphonic acid; R3 is H, optionally substituted C1-6alkyl, C1-6haloalkyl, optionally substituted C3-8cycloalkyl, optionally substituted C6-10aryl, optionally substituted heterocycle, halogen, —OR10, —C2-6alkenyl, —C2-6alkynyl, —CN, —C(O)R11, amine, amide, urea, sulfonamide, sulfone, sulfoxide, sulfide, sulfonic acid, nitro, phosphate or phosphonic acid; R4 is H, optionally substituted C1-6alkyl, C1-6haloalkyl, optionally substituted C3-8cycloalkyl, optionally substituted C6-10aryl, optionally substituted heterocycle, halogen, —OR10, —C2-6 alkenyl, —C2-6 alkynyl, —CN, —C(O)R11, amine, amide, urea, sulfonamide, sulfone, sulfoxide, sulfide, sulfonic acid, nitro, phosphate or phosphonic acid; R5 is H, optionally substituted C1-6alkyl, C1-6haloalkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C6-10aryl, optionally substituted heterocycle, halogen, —OR10, —C2-6alkenyl, —C2-6alkynyl, —CN, —C(O)R11, amine, amide, urea, sulfonamide, sulfone, sulfoxide, sulfide, sulfonic acid, nitro, phosphate or phosphonic acid; R6 is H or optionally substituted C1-6alkyl; R7 is H or optionally substituted C1-6alkyl; R8 is H or optionally substituted C1-6alkyl; R9 is H or optionally substituted C1-6alkyl; a is 0, 1, 2 or 3; R10 is —OH or optionally substituted C1-6alkyl; R11 is —OH, —OC1-6alkyl or optionally substituted C1-6alkyl; or a pharmaceutically acceptable salt thereof; provided that the compound is not of structure: