| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel epothilone derivatives of formula (8) , to synthesis method thereof and use thereof to obtain compounds of formula (9) , as well as to novel intermediate compounds for realising said method and synthesis methods thereof. The abbreviation P in said general structural formulae denotes a protective group of a functional hydroxyl selected from silyl protective groups, R2 denotes a 5-member heteroaryl containing N and S as heteroatoms, optionally substituted with C1-C6 alkyl, and R1 denotes methyl. ^ EFFECT: method of obtaining novel epothilone derivatives is simpler and better, can be well implemented on an industrial scale owing to a shorter synthesis path, and provides high reproducibility of synthesis of highly pure key intermediate compounds and end products. ^ 21 cl, 6 ex |
