Modified small interfering RNA molecules and methods of use

摘要

The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer.

主权项

1. A composition comprising a siRNA to HCV, comprising a first strand and a second strand, wherein the sequence of said first strand is the sequence of SEQ ID NO: 46.