CHROMATIN-ACTIVITY-BASED CHEMOPROTEOMIC (CHAC) METHODS AND SYSTEMS FOR DISEASE MARKER DISCOVERY AND DEVELOPMENT

摘要

Methods for identifying and developing biomarkers based on the characterization of disease-related components of gene-specific chromatin regulatory protein complexs. Chemoprobes that are substrate-competitive and selectively bind enzymatically active enzymes associated with gene-specific chromatin regulatory protein complex can be used to select chromatin complexes associated with a phenotyp of interest.