GAPDH CASCADE INHIBITOR COMPOUNDS AND METHODS OF USE AND TREATMENT OF STRESS INDUCED DISORDERS INCLUDING MENTAL ILLNESS

摘要

The present invention provides compounds and composition comprising analogs of deprenyl and their use in the inhibition of nuclear GAPDH-Siahl binding and the activation of p300 and MEF2. Also provided herein are methods of prevention and treatment of stress induced disorders of the body, including, for example, major mental illness, such as schizophrenia, mood disorders, and addiction, as well as stress-associated diseases involving other organs, such as cardiac hypertrophy, in vivo, comprising administering to a mammal a therapeutically effective amount of analogs of deprenyl.

主权项

1. A method for inhibition of the GAPDH-Siahl in the cells of a subject comprising administering to the subject an effective amount of a pharmaceutical composition comprising a compound of formula I,or formula II wherein R1 to R3 can be the same or different, and can include H, OH, C2-C8 alkyl, C2-C8, alkenyl, C2-C8 alkynyl, substituted C2-C8 alkyl, C2-C8, alkenyl, and C2-C8 alkynyl, and a pharmaceutically acceptable carrier.