| 发明名称 |
Anti Notch-1 antibodies |
| 摘要 |
This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR. |
| 申请公布号 |
US9090690(B2) |
申请公布日期 |
2015.07.28 |
| 申请号 |
US201013378791 |
申请日期 |
2010.06.16 |
| 申请人 |
Pfizer Inc. |
发明人 |
Li Kang;Wei Ping;Peng Qinghai;Lippincott John Andrew;Stone Donna Marie;Hostomsky Zdenek |
| 分类号 |
C07K16/00;C07K16/18;C07K16/28;A61K39/00;A61K39/395;C07K14/705 |
主分类号 |
C07K16/00 |
| 代理机构 |
|
代理人 |
McKeever Carol A. |
| 主权项 |
1. An isolated antibody, or an antigen binding portion thereof, that specifically binds to human Notch-1, wherein the antibody or antigen binding portion binds to at least a first epitope and a second epitope;
wherein the first epitope comprises 1 to 4 amino acid residues selected from amino acid residues 15, 17, 18, and 19 of SEQ ID NO: 23; and wherein the second epitope comprises 1 to 5 amino acid residues of SEQ ID NO: 31. |
| 地址 |
New York NY US |
