DIAGNOSIS OF ACTIVE TUBERCULOSIS BY DETERMINING THE MRNA EXPRESSION LEVELS OF MARKER GENES IN BLOOD

摘要

The present disclosure relates to a method of distinguishing active TB in the presence of a complicating factor, for example, latent TB and/or co-morbidities, such as those that present similar symptoms to TB, such as HIV. The method employs a 27 gene signature to distinguish active tuberculosis from latent TB infection, a 44 gene signature to distinguish active TB from other diseases such as HIV and/or a 53 gene signature to discriminate active TB from latent TB and other diseases. The disclosure also relates to a gene signature employed in the method, a bespoke gene chip for use in the method and a disease risk score obtainable from the method.

主权项

1. A method for detecting active tuberculosis (TB) in a subject derived sample in the presence of a complicating factor, comprising the step of detecting the modulation of at least 60% of the genes in a signature selected from the group consisting of:
a) a 27 gene signature shown in Table 3, b) a 44 gene signature shown in Table 4, c) a 53 gene signature shown in Table 5, d) a combination of signatures a) and b), a) and c), b) and c) or a) and b) and c).