| 发明名称 | Tumor selective E1a and E1b mutants | ||
| 摘要 | Modified E1a regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins. | ||
| 申请公布号 | US9073980(B2) | 申请公布日期 | 2015.07.07 |
| 申请号 | US201013254825 | 申请日期 | 2010.03.02 |
| 申请人 | The Regents of the University of California | 发明人 | Reid Tony;Hedjran Farah;Kumar Shantanu |
| 分类号 | C07K14/005;C12N7/00;C12N15/86;A61K48/00 | 主分类号 | C07K14/005 |
| 代理机构 | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. | 代理人 | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. |
| 主权项 | 1. A recombinant adenovirus-comprising: (i) a DNA sequence inserted into an E1b-19K insertion site, wherein the insertion site is located between the start site of E1b-19K and the start site of E1b-55K; and (ii) a modified E1a regulatory sequence, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. | ||
| 地址 | Oakland CA US | ||