CONTROLLED RELEASE COMPOSITIONS COMPRISING A COMBINATION OF ISOSORBIDE DINITRATE AND HYDRALAZINE HYDROCHLORIDE

摘要

The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.

主权项

1. A controlled release pharmaceutical composition comprising a population of isosorbide dinitrate and hydralazine, or a salt or derivative thereof,—containing particles, wherein at least a portion of the particles incorporate a modified-release coating or, alternatively or additionally, a modified-release matrix material, such that the composition following oral delivery to a subject delivers the isosorbide dinitrate and hydralazine, or salt or derivative thereof, in a pulsatile or zero order manner.