| 发明名称 |
STABLE NON-AGGREGATING NUCLEIC ACID LIPID PARTICLE FORMULATIONS |
| 摘要 |
The present invention relates to stable lipid nanoparticle pharmaceutical formulations which are substantially free of large aggregates (e.g., aggregates greater than 1 μm in size) and include a substantially non-ionic medium. |
| 申请公布号 |
US2015165039(A1) |
申请公布日期 |
2015.06.18 |
| 申请号 |
US201314412957 |
申请日期 |
2013.07.03 |
| 申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
Kumar Varun;Akinc Akin |
| 分类号 |
A61K47/26;A61K47/18;A61K47/10;C12N15/113;A61K9/51 |
主分类号 |
A61K47/26 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A pharmaceutical formulation for parenteral administration comprising
(a) lipid nanoparticles comprising a cationic lipid and a nucleic acid, in (b) a medium, wherein the formulation has one or more of the following characteristics:
(i) the medium is substantially free of anions,(ii) the medium is non-ionic or substantially non-ionic, and(iii) the formulation has a pH less than the pKa of the cationic lipid. |
| 地址 |
Cambridge MA US |
