| 摘要 |
The invention provides a method of reducing anthracycline-induced cardiotoxicity by administering a toxicity-reducing compound, such as a compound of Formulas (I), (II) or (III) or a combination thereof, and/or diphenyl urea (DPU), dexrazoxane (DEX), to a patient receiving an anthracycline. The invention also provides a method of identifying toxicity-reducing compounds. |
| 主权项 |
1. A method of reducing anthracycline-induced cardiotoxicity, comprising administering, to a patient receiving an anthracycline, a compound of Formula (I): or a pharmacecutically acceptable salt thereof, wherein: X1R1 taken together represent C═O, and X2 and X3 together represent C═C; or X3R3 taken together represent C═O, and X2 and X1 form together C═C; and R9 represents H, alkyl, or acyl or, taken together with either R4 or R8 forms a furan ring substituted with R5 and R6; R4 and R8, when not forming a ring with R9, are each independently selected from H, OH, alkyl, acyloxy, and alkoxy; the rest of R1, R2, R3, R5, R6, and R7 are each independently selected from H, OH, alkyl, acyloxy, and alkoxy. |
