METHODS AND MATERIALS FOR INCREASING POTENCY OF CELLS

摘要

Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.

主权项

1. A mesenchymal stem cell possessing increased developmental potency, said mesenchymal stem cell produced by introducing into said mesenchymal stem cell at least one polynucleotide encoding a polypeptide exhibiting dedifferentiating influence, wherein expression of said polynucleotide causes an increase nanog in the mesenchymal stem cell, and wherein said expression results in higher developmental potency of said mesenchymal stem cell.