| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, specifically to N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-ene-1-yl)methyl)piperazine-1-yl)benzoyl)-4-(((1R)-3-(morpholine-4-yl)-1-((phenylsulphanyl)methyl)propyl)-amino)-3-((trifluoromethyl)sulphonyl)benzenesulphonamide (ABT-263) in a solid crystalline form. The invention also relates to a pharmaceutical composition on the basis of the above crystalline forms, suitable for the treatment of diseases, characterised by the apoptosis disorder and/or overexpression of one or more anti-apoptotic Bcl-2 family proteins.EFFECT: obtained new crystalline forms of ABT-263 with useful biological properties.35 cl, 2 dwg, 22 tbl |
