| 摘要 |
FIELD: medicine.SUBSTANCE: group of inventions refers to medicine. Presented are diagnostic technique for chronic obstructive pulmonary disease (COPD) and differentiating stages I/II and III/IV COPD in a human involving measuring heat-shock protein 27 (HSP27), 70 (HSP70) and 90 alpha (HSP90 alpha) and measuring interleukin-1 (ST2) receptor 4 or histon-related DNA fragments in a sample. The COBD is diagnosed, when the measured amount of HSP27, HSP70, HSP90 alpha, ST2 and histon-related DNA fragments appears to increase as compared to that in the healthy people. The stage I/II COBD is diagnosed, when the measured amount of HSP27 in the sample of the above individual falls within 2,600 and 3,300 pg/ml, the amount of ST2 is more than 160 pg/ml, while the amount of HSP70 and HSP90 alpha is at least 40% increased as compared to that in the healthy people. The stage III/IV COBD is diagnosed, when the amount of HSP27 in the sample falls within 3,400 and 5,500 pg/ml, while the amount of HSP70, HSP90 alpha and histon-related DNA fragments is at least 40% increased as compared to that in the healthy people.EFFECT: group of inventions provides the effective diagnostic techniques for the COPD and differentiating between the stages I/II and III/IV COPD in the individual.11 cl, 20 dwg, 2 tbl, 2 ex |
