发明名称 |
Péptidos derivados con A-B-C-D y sus usos terapéuticos |
摘要 |
<p>The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogues thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.</p> |
申请公布号 |
ES2532116(T3) |
申请公布日期 |
2015.03.24 |
申请号 |
ES20080803799T |
申请日期 |
2008.09.05 |
申请人 |
NOVO NORDISK A/S |
发明人 |
SPETZLER, JANE;SCHÄFFER, LAUGE;LAU, JESPER;KRUSE, THOMAS;GARIBAY, PATRICK WILLIAM;ØSTERGAARD, SØREN;RUNGE, STEFFEN;THØGERSEN, HENNING |
分类号 |
A61K38/22;A61K38/26;A61K47/48;C07K14/575;C07K14/605 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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