Multicomponent crystals made of ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and an arylpropionic acid

摘要

The invention relates to novel multicomponent crystals, to the production thereof, and to the use thereof for treating pain conditions, in particular of unclear genesis, by means of a simultaneous effect on pains which are caused by muscle tension or degenerative joint diseases as well as on pains that are caused by inflammatory processes. The multicomponent crystals according to the invention contain ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester (flupirtine) and an arylpropionic acid as the sole active ingredient combination and can be produced by dissolving flupirtine and the arylpropionic acid in an inert organic solvent and subsequently crystallizing the multicomponent crystal.

主权项

1. Multicomponent crystal, characterized in that it contains as a sole active ingredient combination a combination of:
([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]carbamic acid ethyl ester (flupirtine) and the arylpropionic acid
(RS)-2-[4-(2-methylpropyl)-phenyl]propanoic acid (ibuprofen), and further characterized by an X-ray powder diffractogram with a characteristic peak at 2θ=4.7±0.2°.