Bioabsorbable coating with tunable hydrophobicity

摘要

The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.

主权项

1. An implantable medical device, comprising:
a device body; an optional primer layer disposed over the device body; a drug reservoir layer disposed over the device body or the primer layer, if opted, wherein the drug reservoir layer comprises a polymer and a therapeutic agent and further wherein the hydrophobicity of the polymer is matched to that of the therapeutic agent so that the therapeutic agent is miscible with the polymer; wherein the polymer is
poly(L-lactide-co-ε-caprolactone) wherein the molar ratio of L-lactide and ε-caprolactone is from 70:30 to 50:50, orpoly(L-lactide-co-trimethylene carbonate) wherein the molar ratio of L-lactide and trimethylene carbonate is 70:30; wherein the therapeutic agent is everolimus.