| 主权项 |
1. Method of transporting magnetic particles while using a device comprising:
a rotational body configured for a rotation about an axis of rotation; a fluidics structure within the rotational body, said fluidics structure comprising at least first and second fluid chambers, the first and second fluid chambers comprising a fluidic connection in a portion which is located radially inward in relation to the axis of rotation, and being fluidically separated from each other in a portion which is located radially outward in relation to the axis of rotation; and a permanent magnet configured to exert, as a function of a positional relationship between the permanent magnet and the fluidics structure, a magnetic force on magnetic particles arranged in the fluidics structure; and a drive configured to subject the rotational body to rotation about the axis of rotation, the positional relationship between the permanent magnet and the fluidics structure being adjustable as a result, the method comprising:
in a first phase, arranging the first fluid chamber in relation to the permanent magnet in such a manner that, due to the magnetic force, the magnetic particles are transported from a liquid arranged in the radially outer portion of the first fluid chamber into the radially inner portion of the first fluid chamber;in a second phase, changing the positional relationship between the fluidics structure and the permanent magnet by rotating the rotational body such that, due to the magnetic force, the magnetic particles are transported through the fluidic connection between the first and second fluid chambers into the radially inner portion of the second fluid chamber; andin a third phase, subjecting the rotational body to such rotation that the magnetic particles are transported, by means of centrifugal force, from the radially inner portion of the second fluid chamber into a liquid arranged in the radially outer portion of the second fluid chamber, said liquid not being in fluidic contact with the liquid in the first fluid chamber, wherein in the first phase, the magnetic particles are transported across a phase boundary between the liquid in the radially outer portion of the first fluid chamber and a gas in the radially inner portion of the first fluid chamber, and wherein in the third phase the magnetic particles are moved across a phase boundary between a gas in the radially inner portion of the second fluid chamber and the liquid in the radially outer portion of the second fluid chamber, wherein the adjustment of the positional relationship of the permanent magnet and the fluidics structure, which results in the transport of the magnetic particles due to the magnetic force, is effected by rotating the rotational body. |
