METHODS AND COMPOSITIONS FOR EXPANDING LONG-TERM HEMATOPOIETIC STEM CELL POPULATIONS
摘要
The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.
申请公布号
WO2015006762(A1)
申请公布日期
2015.01.15
申请号
WO2014US46498
申请日期
2014.07.14
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;ZHOU, DAOHONG;LUO, YI;SHAO, LIJIAN;FENG, WEI;CHANG, JIANHUI