CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS

摘要

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.

主权项

1. A compound according to the chemical structure: Wherein A is an antibody binding moiety comprising a hapten which is capable of binding to an antibody in a patient; B is a cell binding moiety capable of binding to prostate specific membrane antigen on the cell surface of cells in said patient; L is a linker molecule which links [CON] to A or B in a molecule; [CON] is a bond or a connector molecule linking said linker molecule to A or B; and Each n in a molecule is independently an integer from 1 to 15, Or a pharmaceutically acceptable salt, solvate or polymorph thereof.