| 摘要 |
The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions. |
| 主权项 |
1. The compound of Formula I: where n is an integer from 6-12 inclusive; R1, and R2, are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C1-C10 alkyl, CH3, CHOHCH3, CH(CH3)2, CH2C6H6, and CH2CH(CH3)2; R3, and R4, are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C1-C10 alkyl, C6-C10 aryl or C6-C10 heteroaryl, CH3, CH(CH3)2, CH2CH2OH, CH2CH(CH3)2, and (CH2)2N(CH2CH3)2, wherein if one of R3 and R4 is selected from H, unsubstituted, straight or branched chain C1-C10 alkyl, CH3, CH(CH3)2, and CH2CH(CH3)2, the other is selected from substituted straight or branched chain C1-C10 alkyl, C6-C10 aryl or C6-C10 heteroaryl, CH2CH2OH, and (CH2)2N(CH2CH3)2; R5, and R6, are the same or different and are selected independently from the group consisting of H and CH3, and pharmaceutically acceptable salts thereof. |
