| 摘要 |
A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or NR6, wherein R6 may be H or 20 alkyl.; |
| 主权项 |
1. A synthetically prepared compound according to formula IIa, for the treatment of a disease of the immune system; wherein R6 is hydrogen or C1 to C4 alkyl, R7 is hydrogen or C1 to C4 alkyl, p is from 16 to 30, q is from 8 to 24, r is from 12 to 28 and s is from 12 to 28, and wherein at least 90% of the compound of formula IIa is provided as a single homologue, single regioisomer and/or a single stereoisomer except for the following compounds: |
