| 发明名称 |
IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE |
| 摘要 |
The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof. |
| 申请公布号 |
US2014314711(A1) |
申请公布日期 |
2014.10.23 |
| 申请号 |
US201414214161 |
申请日期 |
2014.03.14 |
| 申请人 |
Genentech, Inc. |
发明人 |
SCHEER JUSTIN;OUYANG WENJUN;VANDLEN RICHARD;HASS PHILIP E.;STEFANICH ERIC GARY;KOLUMAM GANESH A.;WANG XIAOTING;ROSS JED;VAN BRUGGEN NICHOLAS;LEE WYNE P. |
| 分类号 |
C07K16/28;C07K14/54 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An IL-22 Fc fusion protein that binds to IL-22 receptor, said IL-22 Fc fusion protein comprising an IL-22 polypeptide linked to an Fc region by a linker, wherein the Fc region comprises a hinge region, an IgG CH2 domain and an IgG CH3 domain, wherein the IL-22 Fc fusion protein comprises an amino acid sequence having at least 95% sequence identity to the amino acid sequence selected from the group consisting of SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:12 and SEQ ID NO:14, and wherein the Fc region is not glycosylated. |
| 地址 |
South San Francisco CA US |
