| 主权项 |
1. A compound of formula I: a tautomer, N-oxide, or salt thereof, wherein:
ring A is aryl or heteroaryl;n is 0 or 1;
p is 0, 1, 2 or 3 when ring A is monocyclic aryl or heteroaryl or p is 0, 1, 2, 3, 4, or 5 when ring A is bicyclic or tricyclic aryl or heteroaryl;X is selected from the group consisting of alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halo, nitro, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl;Y is O or S;Z is O;W is hydrogen, —SO2N(R4)R5, -alk-SO2N(R4)R5, —N(R4)SO2R5, or -alk-N(R4)SO2R5;
-alk- is selected from the group consisting of straight or branched chain C1-6 alkylene group, and straight or branched chain substituted C1-6 alkylene group;R1 is hydrogen or C1-3 alkyl;
each R2 independently is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkenyl, substituted cycloalkenyl, alkynyloxy, amino, substituted amino, aryl, substituted aryl, aryloxy, substituted aryloxy, cyano, cycloalkyl, substituted cycloalkyl, cycloalkoxy, substituted cycloalkoxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, aminocarbonyl, aminocarbonyloxy, carboxyl, carboxyl ester, (carboxyl ester)oxy, nitro, halo, and oxo, wherein if R2 is oxo, then the oxo substituent is attached to a nonaromatic portion of ring A; orR3 is hydrogen or C1-3 alkyl;
R4 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, acyl and M+, wherein M+ is a counterion selected from the group consisting of K+, Na+, Li+ and +N(R8)4, wherein each R8 is independently hydrogen or alkyl, and the nitrogen of —SO2N(R4)R5 or —N(R4)SO2R5 is N−; andR5 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, amino, alkylamino, dialkylamino, cycloalkylamino, cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and acyl; orR4 and R5 together with the intervening atom or atoms bound thereto form a heterocyclic or a substituted heterocyclic group. |
