| 主权项 |
1. A compound of the formula (I) Cy is aryl, heteroaryl or heterocycle, each is substituted by R1 and optionally substituted by halogen, halo C1-4 alkyl, C1-4 alkyl and C1-4 alkoxy; R1 is chosen from: L-Ar, C1-6 alkyl, —S(O)m—R3 and C1-6 alkoxy, each Ar, C1-6 alkyl and C1-6 alkoxy are optionally substituted by halogen, halo C1-4 alkyl, C1-4 alkyl, R2—S(O)m—, —CN, —C(O)—N(R3)2 or C1-4 alkoxy; L is a linker chosen from a bond, O, >C(O), —(CH2)n—, —O—(CH2)n—, —N(R3)—, —N(R3)—(CH2)n—, —(CH2)n—N(R3)—, —C(O)—N(R3)—, —C(O)—N(R3)—(CH2)n—, —N(R3)—C(O)—N(R3)—, —N(R3)—C(O)—, —S(O)m—N(R3)—, R3—S(O)m—, and —N(R3)—S(O)m—, wherein the —CH2— in each L can have 1-2 hydrogens replaced by C1-3 alkyl, said C1-3 alkyl groups can optionally cyclize to form a C3-6 cycloalkyl ring; Ar is carbocycle, heterocycyl or heteroaryl; Ring A of the formula (I) is an N-linked heterocycle chosen from C5-C10 spirocycle and a nitrogen containing optionally bridged mono- or bi-cyclic heterocycle, each Ring A is substituted by one Y and optionally substituted by halogen, halo C1-4 alkyl, C1-4 alkyl and C1-4 alkoxy; Y is —(CH2)n—N(R3)—R4, or Y is R4, R4 is wherein R5 cannot be hydrogen, each n is independently 1-4; each m is independently 0-2; each R2 and R3 are independently chosen from hydrogen or C1-4 alkyl; each R5 is independently chosen from hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylC1-4alkoxy, C1-4 alkylhydroxy, —(CH2)n-heterocycle and heterocycle each heterocycle optionally substituted by halogen, OH or R2—S(O)m—; each group defined above for Cy, R1-R5, and Y can be where possible partially or fully halogenated; or a pharmaceutically acceptable salt thereof. |
