Biocompatible surgical compositions

摘要

Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses.

主权项

1. A biocompatible surgical adhesive comprising:
an isocyanate-functional methoxy polyethylene glycol combined with at least one multi-functional isocyanate; and at least one diamine, wherein the isocyanate-functional methoxy polyethylene glycol includes degradable linkages and has pendant polyalkylene oxide groups, and wherein the biocompatible surgical adhesive further comprises an enzyme which increases the degradation rate of the degradable linkages.