| 主权项 |
1. A method for treating itchy scalp and/or preventing dandruff, which comprises applying an effective amount of a composition to the scalp of a subject in need thereof, wherein the composition comprises L-menthol and a prostaglandin compound as shown by the following formula (I): wherein L, M and N are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl, lower alkanoyloxy or oxo, wherein at least one of L and M is a group other than hydrogen, and the five-membered ring may have at least one double bond; A is —CH3, or —CH2OH, —COCH2OH, —COOH or a functional derivative thereof; B is —CH2—CH2—, —CH═CH— or —C≡C—; Z1 and Z2 are oxygen, nitrogen or sulfur; R2 and R3 are lower alkyl, which are optionally linked together to form lower alkylene; R1 is a saturated or unsaturated bivalent lower or medium aliphatic hydrocarbon residue, which is unsubstituted or substituted with halogen, alkyl, hydroxy, oxo, aryl or heterocyclic group, and at least one of carbon atom in the aliphatic hydrocarbon is optionally substituted by oxygen, nitrogen or sulfur; and Ra is a saturated or unsaturated lower or medium aliphatic hydrocarbon, which is unsubstituted or substituted with halogen, oxo, hydroxy, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, aryloxy, heterocyclic group or heterocyclic-oxy group; lower alkoxy; lower alkanoyloxy; cyclo(lower)alkyl; cyclo(lower)alkyloxy; aryl; aryloxy; heterocyclic group; heterocyclic-oxy group. |
