发明名称 |
MODIFIED ALBUMIN-BINDING DOMAINS AND USES THEREOF TO IMPROVE PHARMACOKINETICS |
摘要 |
<p>The present invention relates to compositions and methods comprising a modified albumin-binding domain to improve the pharmacokinetic properties of therapeutic molecules. The modified peptides show reduced immunogenicity and/or proved solubility. In particular, compositions and methods for enhancing therapeutic potential of protein therapeutics are provided including linking a protein albumin-binding domain, which has been modified to reduce immunogenicity and/or improve solubility, to a therapeutic protein, including therapeutic antibodies, antibody fragments, antibody single domains and/or dimers of antibody single domains. These linked polypeptides can exhibit enhanced serum half life without exacerbated immunogenicity and/or without decreased solubility, and without substantially affecting the specific binding properties of the therapeutic protein.</p> |
申请公布号 |
SG11201400881S(A) |
申请公布日期 |
2014.04.28 |
申请号 |
SG11201400881S |
申请日期 |
2012.09.19 |
申请人 |
TECHNOPHAGE, INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA |
发明人 |
CASTANHEIRA AIRES DA SILVA, FREDERICO NUNO;VOLKER CÔRTE-REAL, SOFIA;FERREIRA LLORENTE GRANCHO LOURENÇO, SARA |
分类号 |
C07K14/315;A61K39/395;C07K16/24;C07K19/00 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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