CISPLATIN COMPLEX AND PREPARATION METHOD THEREOF

摘要

Provided in the present invention are a cisplatin complex which is formed by cisplatin and a polymer of the structure of formula (I), and the method for preparing the cisplatin complex, which comprises a coordination reaction of cisplatin with the polymer of the structure of formula (I) in an aqueous medium, resulting in the cisplatin complex. The cisplatin complex has good biocompatibility and is degradable; the side chain of the polymer is grafted with polyethylene glycol, thus the prepared cisplatin complex has good solubility; when the cisplatin complex is dissolved in an aqueous medium, the cisplatin is protected by a hydrophilic polyethylene glycol chain segment and a hydrophobic amino acid chain segment, which can effectively avoid a sudden release of the cisplatin due to the influence of the blood circulation system after intravenous injection, thus improving the stability of the cisplatin complex. Additionally, the carboxyl contained in the cisplatin complex provided in the present invention is sensitive to pH values and tends to deprotonate in a low pH environment, which favors the release of the drug and improves the efficiency of the drug.