发明名称 METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS
摘要 A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims, comprises the step of: a) cyclizing a compound represented by Structural Formula A: under suitable reductive cyclisation conditions to form a compound represented by Structural Formula B: wherein R10 is LG1 or —X1R1, and -LG1 is a suitable leaving group; and b) optionally, when R10 of Structural Formula (B) is LG1, further comprising the step of replacing the -LG1 of Structural Formula (B) with —X1R1 to form the compound represented by Structural Formula (I).
申请公布号 ZA201201978(B) 申请公布日期 2013.12.23
申请号 ZA20120001978 申请日期 2012.03.16
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 CHARRIER JEAN-DAMIEN;DURRANT STEVEN;KAY DAVID
分类号 C07D 主分类号 C07D
代理机构 代理人
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