Fremgangsmåde til krystallisation for 1-(b-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-fluorphenyl)-2- thienylmethyl]benzen
摘要
The present invention relates to a crystallization procedure to obtain 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene hemihydrate crystals having a narrow particle size distribution and improved flowability, bulk and tap density properties.
申请公布号
DK2451797(T3)
申请公布日期
2013.06.24
申请号
DK20100729901T
申请日期
2010.07.08
申请人
JANSSEN PHARMACEUTICA, N.V.
发明人
RAMMELOO, THOMAS JOACHIM LANDEWALD;DE KEYSER, RUBEN;SCHILDERMANS, GUSTAAF JOZEF PETRUS