发明名称 |
Drug delivery through hydrogel plugs |
摘要 |
An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
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申请公布号 |
US8409606(B2) |
申请公布日期 |
2013.04.02 |
申请号 |
US20100704692 |
申请日期 |
2010.02.12 |
申请人 |
SAWHNEY AMARPREET S.;JARRETT PETER;BASSETT MICHAEL;BLIZZARD CHARLES;INCEPT, LLC |
发明人 |
SAWHNEY AMARPREET S.;JARRETT PETER;BASSETT MICHAEL;BLIZZARD CHARLES |
分类号 |
A61F2/00;A01N37/08;A01N43/42;A61K31/215;A61K31/44;B29B9/06 |
主分类号 |
A61F2/00 |
代理机构 |
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代理人 |
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地址 |
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