NEBULIZABLE TUBERCULOSIS VACCINE FOR TRANSNASAL ADMINISTRATION COMPRISING PARAMYXOVIRUS VECTOR

摘要

Disclosed is a intranasal spray-type tuberculosis vaccine, which has a high prophylactic effect on human tuberculosis, particularly adult tuberculosis. The nebulizable tuberculosis vaccine for intranasal administration comprises a paramyxovirus gene (particularly rhPIV2) having, integrated therein, a gene encoding an ± antigen derived from an acid-fast bacterium (e.g., an ± antigen derived from Mycobacterium kansasii or Mycobacterium bovis BCG), an analogue of the gene, or a variant of the gene which has an equivalent function to that of the gene.